studying the heterogeneity of the chromosomal instability syndrome, Ataxia-Telangiectasia (A-T), and the role of the ATM (Ataxia-Telangiectasia Mutated) gene in sporadic leukaemia. He subsequently joined the laboratory of Professor Malcolm Taylor at the University of Birmingham to do a Ph.D. Professor Grant Stewart received his first degree in Cellular and Molecular Pathology at the University of Bristol (1996). Importantly, our in depth understanding of the DDR is now being utilised therapeutically and has led to the generation of highly specific inhibitors that are being successfully used to selectively target DNA repair deficient tumours. Studying these rare human diseases has provided a wealth of invaluable information about how defects affecting the cellular DNA damage response (DDR) contribute to neuro-degeneration, abnormal brain development, immune system dysfunction, growth failure, infertility and cancer development.
In this respect Professor Stewart's laboratory has had a long-standing interest in rare human diseases associated with defective DNA repair and/or abnormal DNA replication such as Ataxia-Telangiectasia, Fanconi Anaemia, Seckel Syndrome and Microcephalic Primordial Dwarfism.
Professor Stewart's research focuses on understanding how the cell detects and repairs damage to its DNA and how defects in this process contribute to the development of human disease. Professor Grant Stewart is a Professor of Cancer Genetics in the Institute of Cancer and Genetic Sciences.ĭefective repair of DNA damage is the most frequent underlying cause of genetic instability and cancer development.
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